LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer?
نویسندگان
چکیده
منابع مشابه
LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer?
Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons are insertional mutagens capable of altering the genomic landscape in many ways. Activation of the normally silent LINE-1 retrotransposon is associated with a high level of cancer-associated DNA damage and genomic instability. Studies of LINE-1 have so far focused mainly on changes in gene expression, and our knowledge of its i...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2014
ISSN: 1664-8021
DOI: 10.3389/fgene.2014.00338